Dataset S1. Differentially Expressed Genes in E. cloacae upon interaction with Noroviruses as determined by RNA-seq

Many enteric viruses have been shown to bind to commensal bacteria, which may facilitate enhancement of viral infection. Given the ability of these bacteria to rapidly respond to external stimuli, we hypothesized the viral binding would induce changes in bacterial gene expression. These data demonstrate that binding of both murine and human noroviruses to E. cloacae induces global changes in gene expression by the commensal bacterium.

已有研究证实，多种肠道病毒（enteric viruses）可与共生细菌（commensal bacteria）结合，该相互作用或可促进病毒感染的增强。鉴于这类细菌可快速响应外界刺激（external stimuli），我们提出假说：病毒与细菌的结合会诱导细菌基因表达（bacterial gene expression）发生改变。本研究数据表明，鼠源诺如病毒与人类诺如病毒结合阴沟肠杆菌（E. cloacae）后，均可诱导该共生细菌发生全基因组范围的基因表达改变。