<b>Effect of different concentrations of chloroprocaine on muscle strength of quadriceps femoris during postoperative functional training of knee joint</b>

Purpose: To compare the effects of different concentrations of chloroprocaine femoral nerve block (FNB) on the muscle strength of quadriceps femoris in early large-angle knee function training. Materials and methods: A total of 90 patients who underwent early large angle rehabilitation training 48 hours after total knee arthroplasty (TKA)were randomly divided into three groups. Before training, 1% chloroprocaine 0.2 ml/kg (C1 group), 2% chloroprocaine 0.2 ml/kg (C2 group) and 0.2 ml/kg of normal saline (NS group) were injected into the femoral nerve catheterization, and active exercise was carried out after 10min. The Lotte muscle strength method was used to evaluate the muscle strength and able to start training time was recorded. Results: 84 patients who completed the study were divided into C1 group (n = 28), C2 group (n = 29) and NS group (n = 27). There was significant difference in muscle strength among the three groups at 30min and 60min time point (P &lt; 0.05). Compared with C2 group and NS group, C1 group decreased significantly (P &lt;0. 0167). Conclusion: 1% chloroprocaine 0.2 ml/kg femoral nerve injection has a slight effect on the quadriceps femoris, which can cooperate with early postoperative knee joint rehabilitation training.研究目的：对比不同浓度氯普鲁卡因股神经阻滞（Femoral Nerve Block, FNB）对全膝关节置换术（Total Knee Arthroplasty, TKA）后早期大角度膝关节功能训练中股四头肌肌力的影响。 材料与方法：选取90例全膝关节置换术后48小时即开展早期大角度康复训练的患者，按随机分组原则分为三组。训练前，分别经股神经导管给药：1%氯普鲁卡因0.2ml/kg（C1组）、2%氯普鲁卡因0.2ml/kg（C2组）以及0.2ml/kg生理盐水（Normal Saline, NS），给药10分钟后启动主动运动训练。采用洛特（Lotte）肌力评定法评估股四头肌肌力，并记录患者可启动训练的时间。 结果：最终共84例患者完成本研究，其中C1组28例、C2组29例、NS组27例。在给药后30分钟、60分钟两个时间点，三组患者的股四头肌肌力差异均具有统计学意义（P<0.05）。与C2组及NS组相比，C1组肌力下降程度显著更低（P<0.0167）。 结论：1%氯普鲁卡因0.2ml/kg股神经给药对股四头肌肌力影响轻微，可配合术后早期膝关节康复训练开展。