Comparisons of retinal nerve fiber layer thickness changes after macular hole surgery

ABSTRACT Purpose: To compare postoperative changes in retinal nerve fiber layer thickness in patients with macular holes treated with vitrectomy with Brilliant Blue-assisted internal limiting membrane peeling. Methods: Twenty-two eyes of 20 patients with macular holes were studied. Each eye was selected to undergo Brilliant Blue-assisted internal limiting membrane peeling. The circumferential retinal nerve fiber layer thickness was determined using spectral domain optical coherence tomography preoperatively and 2 months postoperatively. Mean overall and sectoral retinal nerve fiber layer thicknesses were obtained for each patient. Results: There was no statistically significant difference (p≥0.05) between the pre- and post-treatment measurements in relation to each CFN variable, i.e., on average, pre-treatment measures were the same as post-treatment measures. Furthermore, despite the differences between the pre- and post-treatment measures always being positive (pre-post >0), they are not statistically significant. Conclusions: This study showed no significant decrease in retinal nerve fiber layer thickness measurements after macular holes surgery, regardless of age or sex.

摘要
研究目的：本研究旨在对比接受亮蓝（Brilliant Blue）辅助内界膜剥除联合玻璃体切割术治疗的黄斑裂孔患者，其视网膜神经纤维层厚度的术后变化情况。
研究方法：本研究纳入20例黄斑裂孔患者的22只患眼，所有患眼均接受亮蓝辅助内界膜剥除术。分别于术前及术后2个月，采用光谱域光学相干断层扫描（spectral domain optical coherence tomography）测量环形视网膜神经纤维层厚度，并计算每位患者的整体及分区视网膜神经纤维层平均厚度。
研究结果：各CFN变量的术前与术后测量值之间均无统计学显著性差异（p≥0.05），即平均而言，术前测量值与术后测量值无明显差异。此外，尽管术前与术后测量值的差值始终为正值（术前值-术后值>0），但该差值仍无统计学显著性。
研究结论：本研究表明，无论患者年龄或性别如何，黄斑裂孔手术后的视网膜神经纤维层厚度测量值均未出现显著降低。