Table 1_Central line-associated bloodstream infection rates in intensive care units of China’s hospitals: a meta-analysis.docx

Background and aimVarious reasons have hindered accurate reporting of the central line-associated bloodstream infection (CLABSI) rates in China’s hospital ICUs. This study conducts a meta-analysis to provide a precise assessment of CLABSI rates in these units.
MethodsAdhering to the PRISMA guidelines, a systematic search was conducted in PubMed, Web of Science, Embase, CNKI, Wanfang and Weipu from January 2008 to December 2023. Selection of literature followed strict criteria, ensuring relevant data extraction. A random-effects model facilitated the meta-analysis.
ResultsThe analysis incorporated 23 studies (PubMed: 5, Web of Science: 4, Embase: 1, CNKI: 9, Wanfang: 2, Weipu: 2). It revealed an overall weighted CLABSI rate in China’s ICUs of 2.65‰ (95% CI: 2.57–2.73‰), with 3.12‰ in adult ICU (95% CI: 2.70–3.54‰) and 2.57‰ in pediatric ICUs (95% CI: 2.49–2.66‰). Notably, adult ICUs in North of China recorded the highest rate at 5.13‰ (95% CI: 4.23–6.02‰), and pediatric ICUs in East of China had 3.35‰ (95% CI: 2.85–3.85‰).
ConclusionThe study indicates that CLABSI rates in China’s ICUs surpass those reported in national healthcare reports and the US CDC-NHSN data. This underscores the urgency for enhanced surveillance and infection control. The findings stress the need for standardized surveillance definitions and methods to truly represent CLABSI epidemiology and develop effective prevention strategies.

研究背景与研究目的：多种因素制约了中国医院重症监护室（ICU）内中心静脉导管相关血流感染（CLABSI, central line-associated bloodstream infection）发生率的准确报告。本研究通过开展荟萃分析，对上述科室的CLABSI发生率进行精准评估。
研究方法：本研究遵循PRISMA声明规范，于2008年1月至2023年12月期间，在PubMed、Web of Science、Embase、中国知网（CNKI）、万方数据（Wanfang）及维普网（Weipu）中开展系统性文献检索。研究严格遵循纳入排除标准筛选文献，并提取相关研究数据；采用随机效应模型完成荟萃分析。
研究结果：本研究共纳入23项相关研究（PubMed数据库5篇、Web of Science数据库4篇、Embase数据库1篇、CNKI数据库9篇、万方数据2篇、维普网2篇）。分析结果显示，中国医院ICU整体加权CLABSI发生率为2.65‰（95%置信区间：2.57~2.73‰），其中成人ICU为3.12‰（95%置信区间：2.70~3.54‰），儿科ICU为2.57‰（95%置信区间：2.49~2.66‰）。值得注意的是，中国北方地区成人ICU的CLABSI发生率最高，达5.13‰（95%置信区间：4.23~6.02‰）；中国东部地区儿科ICU发生率为3.35‰（95%置信区间：2.85~3.85‰）。
研究结论：本研究表明，中国医院ICU的CLABSI发生率高于国内医疗保健报告及美国疾病控制与预防中心国家医疗安全网络（US CDC-NHSN）公布的数据，凸显了强化感染监测与防控工作的紧迫性。本研究结果强调，亟需建立标准化的监测定义与方法，以准确反映CLABSI的流行病学特征，并制定有效的预防策略。