Structural Biology in Marseille

The BAG groups 9 teams from 6 Marseille laboratories. Mutual understanding amongst all PIs provides a solid base for efficient organization of the BAG. Research revolves around infection, health and biotechnology. For the next beam time allocation period (6 months) we could make efficient use of 12 MX and 2 SAXS shifts. Three teams combine structural biology with medicinal chemistry and beam time at MASSIF for large ligand-screening campaigns will mostly suit their purpose. Access to beamlines with tunable energy will be instrumental for projects requiring experimental phasing. One team uses exclusively Bio-SAXS. Allocation of one shift per session would be welcomed. Remote access for MX sessions has become very popular whereas scientists prefer to be on-site for Bio-SAXS experiments. The BAG uses also beam time at Synchrotron SOLEIL and overlap in experiment scheduling engenders in certain instances beam time cancellations.

BAG汇集了来自马赛6家实验室的9个研究团队。全体首席研究员（Principal Investigator，PI）之间的相互共识与协同，为BAG的高效运转奠定了坚实基础。该协作组的研究方向围绕感染、健康与生物技术领域展开。在接下来的6个月束流时长分配周期内，本协作组可高效利用12次大分子晶体学（Macromolecular Crystallography，MX）束流时段与2次小角X射线散射（Small Angle X-ray Scattering，SAXS）束流时段。其中3个团队将结构生物学与药物化学相结合，MASSIF光束线的束流时段可充分满足其大规模配体筛选实验的需求。具备可调能量特性的光束线，将为需要实验相位测定的研究项目提供关键支撑。另有1个团队仅开展生物小角X射线散射（Bio-SAXS）相关研究，该团队希望每个实验周期可获得1次束流时段的分配。目前，大分子晶体学实验的远程访问模式已广受欢迎，而生物小角X射线散射实验则更倾向于科研人员现场开展。此外，BAG同时会使用索雷尔同步辐射源（Synchrotron SOLEIL）的束流时段，实验排期的重叠在部分情况下会导致束流时段被取消。