Genome-wide small RNA sequencing of proliferative and replicative senescent human vascular smooth muscle cells and exosomes

We report high-throughput sequencing of small RNAs can compare the profiles between proliferative and replicative senescent human vascular smooth muscle cells and exosomes Examination of differentially expressed miRNAs of proliferative and replicative senescent hVSMCs and their exosomes.

本研究通过小RNA（small RNA）高通量测序技术，比较了增殖态与复制衰老态人血管平滑肌细胞（human vascular smooth muscle cells, hVSMCs）及其外泌体（exosomes）的小RNA表达谱，并针对上述两类细胞及其外泌体中的差异表达微小RNA（microRNA, miRNA）进行了分析。