Fold change in the number of free miRNA and ceRNAs.

Using ceRNA1 transcription rate as control parameter we evaluate the fold change in the number of free miRNA (S), ceRNA1 () and ceRNA2 () upon a variation of 2,5 and 7 fold in in a system of 1 miRNA interacting with 100 different targets (). Depending on the availability of free miRNA S (which depends on its basal transcription rate ) the system could be below, near or above the threshold. Although the fold-change in is the same in the three cases, the fold change in and (measured as the ratio between their final and initial values) is maximal in proximity to the threshold. To obtain approximately the same fold-change in a system with only 1 miRNA and 2 targets ( and ) the miRNA transcription rate has to be lower. Its value is reported in brackets as well the corresponding fold-change when different from the case with 1 miRNA and 100 targets.以内源竞争RNA（competing endogenous RNA，ceRNA）1的转录速率作为对照参数，我们针对1个微小RNA（microRNA，miRNA）与100种不同靶标（）相互作用的系统，评估了当系统参数发生2、5、7倍变化时，游离miRNA（S）、ceRNA1（）与ceRNA2（）的数量倍数变化情况。根据游离miRNA S的可获得性（其取决于自身基础转录速率），该系统可分为阈值以下、阈值附近与阈值以上三种状态。尽管三种情形中原文缺失参数的倍数变化保持一致，但以最终值与初始值的比值作为衡量标准的原文缺失分子的倍数变化，在阈值附近达到最大值。若要在仅包含1个miRNA与2个靶标（和）的系统中获得近似相同的倍数变化，则miRNA的转录速率需更低。其取值标注于括号内，同时一并标注的还有与"1个miRNA对应100个靶标"的情形存在差异时的对应倍数变化。