Supplementary Material for: Recurrence of large-vessel vasculitis induced by multiple types of Granulocyte colony-stimulating factor preparation in patient with large cell neuroendocrine lung carcinoma: a case report

With the increased use of granulocyte colony-stimulating factor (G-CSF) preparations, there is concern about the increase in G-CSF-associated large-vessel vasculitis; however, there have been no previous reports of vasculitis caused by multiple types of G-CSF preparations. We experienced a case of drug-induced large-vessel vasculitis caused by two different G-CSF products, which was difficult to diagnose. When treating patients with a history of large-vessel vasculitis caused by pegfilgrastim, we need to pay attention to its recurrence when using other G-CSF preparations.

随着粒细胞集落刺激因子（granulocyte colony-stimulating factor，G-CSF）制剂的临床应用日益普及，临床对G-CSF相关大血管血管炎的担忧亦随之增加，但此前尚无由多种类型G-CSF制剂诱发血管炎的相关报道。本次我们收治了一例由两种不同G-CSF产品引发的药物性大血管血管炎病例，该病例诊断难度较高。对于曾因培非格司亭（pegfilgrastim）引发大血管血管炎的患者，在使用其他G-CSF制剂时，需警惕疾病复发。