Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization

In this study, we investigated CNAs of 40 tumor samples from 25 patients, including 15 metastatic primary tumor (MPT), paired neck lymph-node metastasis (LNM) and 10 non-metastatic primary tumor (NMPT), by 44k oligonucleotide-based array comparative genomic hybridization (array CGH). 15 MPT vs 15 LNM, 10 NMPT vs 15 LNM

本研究中，我们通过44k寡核苷酸阵列比较基因组杂交（array comparative genomic hybridization, array CGH）技术，对25名患者的40份肿瘤样本的拷贝数变异（Copy Number Alterations, CNAs）进行了分析，这批样本包含15份转移性原发肿瘤（metastatic primary tumor, MPT）、配对的颈部淋巴结转移瘤（neck lymph-node metastasis, LNM）以及10份非转移性原发肿瘤（non-metastatic primary tumor, NMPT）。本研究开展了两组对照分析：15份MPT与15份LNM的对照，以及10份NMPT与15份LNM的对照。