SH3KBP1 controls skeletal myofibers formation and functionality through ER/SR architecture integrity

Myofibers formation depends on various molecular processes in which the dynamics of organelles, such as myonuclei and reticula remodeling are key processes to maintain muscular functions. Guiraud, Couturier, et al show that SH3KBP1 controls myofiber integrity by the regulation of myoblast fusion, myonuclear localization and ER architecture in the early course of myofiber formation and later, through the maintenance and function of triads architecture.

肌纤维形成依赖于多种分子过程，其中细胞器（organelles）的动态变化——如肌核（myonuclei）与内质网（Endoplasmic Reticulum, ER）重塑——是维持肌肉功能的关键环节。吉罗（Guiraud）、库蒂尔（Couturier）等人的研究表明，SH3KBP1可在肌纤维形成早期通过调控成肌细胞融合、肌核定位与内质网结构，在形成后期通过维持三联管结构的功能与完整性，从而调控肌纤维的完整性。