Salinispora arenicola CNY260. Salinispora arenicola CNY260

Multiplexed sequencing for secondary metabolite discovery: the goal of this project is to generate draft genome sequences for 144 or more cultured marine actinomycetes. The focus is on the genus Salinispora, which has proven to be a rich source of unusual secondary metabolites. Multiple strains derived from different locations will provide opportunities to assess the ¿secondary metabolome¿ of a well-defined bacterial lineage and to better understand pathway evolution and how it generates structural complexity. This project provides a unique opportunity to apply genome-mining approaches to natural product discovery and to use population genomics to explore fundamental questions related to the ecology and evolution of bacteria.

面向次生代谢产物发掘的多重测序项目：本项目的目标是为144株及以上已培养的海洋放线菌绘制草图基因组序列。研究聚焦于盐孢菌属（Salinispora），该属已被证实是非常规次生代谢产物的丰富来源。从不同地理位置分离得到的多株菌株，将为解析一类定义明确的细菌类群的次生代谢组提供契机，并助力我们更深入地理解代谢途径的演化及其如何造就结构复杂性。本项目为将基因组挖掘方法应用于天然产物发掘，以及借助群体基因组学探究与细菌生态学及演化相关的基础问题，提供了绝佳的研究契机。