Abnormal histological findings - Female, 49 - Tissue image [6090730014736031]

This is the histopathological image of CERVIX UTERI tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: VS200 Olympus slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 49Clinical description: Cervical dysplasia, HSILGender: FemaleDiagnosis:Classification: ICD-10_10-20Classification code: Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classifiedDiagnosis: Abnormal histological findingsResult of the histopathological examination: Foci of high-grade dysplasia (HSIL / CIN III), located near the transformation zone - IHC: p16 + (block reaction), increased Ki67 index,
present throughout the full thickness of the epithelium. Dysplastic changes do not reach the surgical margin of the endocervix. Features of mature and immature squamous metaplasia and a moderate chronic inflammatory infiltrate.Sample:Material: FFPECollecting method: Surgical specimenTopography: FEMALE GENITAL ORGANSOrgan: CERVIX UTERITissue: ExocervixType of staining: positive/HEStaining: Not applicableAntibody: Not applicableTechnology:Equipment: VS200 OlympusLens: 20xOrganization:Source: Medical University Gdańsk

本数据集为格但斯克医科大学（Medical University Gdańsk）采集并存档于ZMDL-GUMED的子宫颈（CERVIX UTERI）组织样本的组织病理学图像。该样本图像通过奥林巴斯VS200切片扫描仪（VS200 Olympus slide scanner）以20倍放大倍率采集，存储格式为DICOM（医学数字成像和通信格式）。

患者及诊断详细信息如下：
患者：年龄49岁，女性；临床诊断为宫颈发育异常、高级别鳞状上皮内病变（HSIL）。
诊断分类：采用ICD-10_10-20分类标准，分类编码为第十八章——其他未特指的症状、体征及临床和实验室异常发现。
最终诊断：组织学检查存在异常表现。
组织病理学检查结果：可见高级别发育异常灶（HSIL/CIN III，宫颈上皮内瘤变III级），位于宫颈转化区附近；免疫组化（IHC）检测显示p16呈阳性（块状染色反应），Ki67增殖指数升高，累及上皮全层。发育异常病变未累及宫颈内口手术切缘，同时可见成熟与未成熟鳞状上皮化生改变，伴中度慢性炎性浸润。

样本详情：
样本材质为福尔马林固定石蜡包埋（FFPE）组织，采集方式为手术标本，解剖部位为女性生殖器官，对应器官为子宫颈，组织类型为宫颈外膜（Exocervix）。
染色类型为HE染色（positive/HE），无需额外染色操作，无需使用特异性抗体；相关成像设备为奥林巴斯VS200切片扫描仪，镜头放大倍率为20倍，数据来源机构为格但斯克医科大学。