Genes-Environments and Admixture in Latino Asthmatics (GALA II) Study

A case-control pharmacogenetic study of bronchodilator drug response among racially admixed Latino children with asthma. Each participant had two spirometry measurements using the KoKo PFT System. With the first spirometry test, participant was administered with 4 puffs of HFA Albuterol. The second albuterol measurement was based on age, for participants under 16 years of age, additional 2 puffs were administered and for those over 16 years of age, additional 4 puffs were administered. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants are 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications.

The GALAII Study is utilized in the following dbGaP substudies. To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001180 GALAII Study. - [phs001274](./study.cgi?study_id=phs001274)phs001274 GALAII GWAS

本研究为一项针对种族混血拉丁裔哮喘儿童支气管扩张剂药物反应的病例对照药物基因组学研究。所有受试者均采用KoKo PFT系统完成两次肺量测定：首次肺量测定前，受试者吸入4揿HFA沙丁胺醇；第二次沙丁胺醇给药剂量根据年龄调整——16岁及以下受试者额外吸入2揿，16岁以上受试者额外吸入4揿。本研究的核心目标为鉴定可预测哮喘儿童药物反应的遗传因素，主要研究手段包括问卷调查与生物样本采集。受试者招募时年龄为8至21岁，纳入的哮喘患儿均经医师确诊哮喘，且存在相关症状与用药史。

本研究数据被应用于以下dbGaP子研究。若需查看这些子研究中收录的基因型、分析数据、其他分子数据及衍生变量，请点击本顶层研究页面（phs001180 GALAII研究）右侧「子研究」板块或下方链接对应的子研究：
- [phs001274](./study.cgi?study_id=phs001274) phs001274 GALAII全基因组关联研究（Genome-Wide Association Study, GWAS）