Research data supporting "MICA: Synovial fibroblast pain pathotypes: A roadmap to understanding and targeting the complexity of patient-reported joint pain in osteoarthritis" and associated publications

This study contains pain data and tissue samples from patients with knee osteoarthritis, including questionnaires (EQ5D, OKS, VAS), synovitis scores, and transcriptomic data of synovial tissues from patient-reported sites of pain and no pain using bulk and single-cell RNAseq, as well as corresponding biobank containing patient serum, synovial fluid, synovium and adipose tissues.

本研究收录膝骨关节炎患者的疼痛相关数据与组织样本，涵盖临床问卷（EQ5D、OKS、VAS）、滑膜炎评分，以及针对患者自述的疼痛部位与无痛部位的滑膜组织的转录组学数据，该数据通过批量RNA测序（bulk RNAseq）与单细胞RNA测序（single-cell RNAseq）技术获取；同时配套建立了包含患者血清、滑液、滑膜及脂肪组织的生物样本库。