Analysis of genes encoding components of major developmental signaling pathways.

The number of orthologs encoding various Wnt, non-canonical Wnt, Notch, Jak-STAT, Hedgehog, Receptor tyrosine kinase, and TGFβ signaling pathway components are indicated for each of the three mosquito species. Numbers refer to the number of orthologous sequences present in the three mosquito genomes for each D. melanogaster gene indicated at left. Results are reported only for genes in which the number of orthologous sequences varies between D. melanogaster and at least one of the mosquito species. Although the pathway components are generally very well conserved, changes in the number of orthologous sequences for several genes encoding components of the indicated signaling pathways (most notably Wnt, Notch, and FGF) were observed.