Analysis of genes encoding components of major developmental signaling pathways.

The number of orthologs encoding various Wnt, non-canonical Wnt, Notch, Jak-STAT, Hedgehog, Receptor tyrosine kinase, and TGFβ signaling pathway components are indicated for each of the three mosquito species. Numbers refer to the number of orthologous sequences present in the three mosquito genomes for each D. melanogaster gene indicated at left. Results are reported only for genes in which the number of orthologous sequences varies between D. melanogaster and at least one of the mosquito species. Although the pathway components are generally very well conserved, changes in the number of orthologous sequences for several genes encoding components of the indicated signaling pathways (most notably Wnt, Notch, and FGF) were observed.本数据集明确了三种蚊虫各自所携带的、编码Wnt信号通路（Wnt）、非经典Wnt信号通路（non-canonical Wnt）、Notch信号通路（Notch）、Jak-STAT信号通路（Jak-STAT）、Hedgehog信号通路（Hedgehog）、受体酪氨酸激酶（Receptor tyrosine kinase）以及转化生长因子β（TGFβ）信号通路组分的直系同源基因（ortholog）数量。此处数值对应左侧标注的每个黑腹果蝇（D. melanogaster）基因，在三种蚊虫基因组中所存在的直系同源序列数目。本结果仅统计那些在黑腹果蝇与至少一种蚊虫物种间，直系同源序列数目存在差异的基因。尽管上述信号通路组分通常具有极高的序列保守性，但本研究仍观测到，若干编码上述标注信号通路组分的基因（尤以Wnt、Notch及成纤维细胞生长因子（FGF）相关基因为显著）的直系同源序列数目发生了变化。