CUT&RUN of the kidneys from diabetic mice with MAT2A inhibitor I

H3K27me3 was enhanced in the gene loci related to the inflammatory pathway. SGTL2 WT and MT mice were fed with HFD for 18 weeks.

在与炎症通路相关的基因位点（gene loci）处，组蛋白H3第27位赖氨酸三甲基化（H3K27me3）的修饰水平上调。将SGTL2野生型（wild type, WT）与突变型（mutant type, MT）小鼠以高脂饮食（High Fat Diet, HFD）喂养18周。