Preparation and Phytotoxicity Evaluation of 11,13-Dehydro <i>seco</i>-Guaianolides

11,13-Dehydro seco-guaianolides, a particular type of sesquiterpene lactones, were synthesized from the commercially available α-santonin (11) using a facile strategy involving a high-yielding photochemical reaction. Natural products 10 and 17 from Artemisia gorgonum were synthesized in good yields. Specifically, compound 10 was obtained in five steps with an overall yield of 17%. The sesquiterpene lactones were tested in the etiolated wheat coleoptile bioassay, and the most active compounds were assayed on standard target species. Guaianolide 13 showed the highest phytotoxic activities when compared with the known herbicide Logran.11,13-脱氢断愈创木内酯（11,13-Dehydro seco-guaianolides）是一类特殊的倍半萜内酯（sesquiterpene lactones）。本研究以市售的α-山道年（α-santonin，11）为起始原料，通过一条包含高产率光化学反应的简便合成策略完成了该类化合物的制备。研究人员同时以良好收率完成了源自戈贡蒿（Artemisia gorgonum）的天然产物10与17的全合成，其中化合物10经五步反应得到，总收率达17%。随后，对所合成的倍半萜内酯开展了黄化小麦胚芽鞘生物测定实验，并对其中活性最优的化合物进行了标准靶标物种的活性验证。相较于市售除草剂草净津（Logran），愈创木内酯（Guaianolide）13展现出最高的植物毒性活性。