Myeloid cells single-cell RNA sequencing of distinct Multipe Sclerosis subtypes

This study investigates monocyte alterations in Multiple Sclerosis (MS) progression using single-cell RNA sequencing of myeloid cells from Relapsing-Remitting MS, progressive MS, and healthy controls. We have been able to subdivide patients classified as progressive MS into two distinct groups: clinical progressor and non-progressors, based on having or not sustained disability worsening over the last 6 months.

本研究通过对复发缓解型多发性硬化（Relapsing-Remitting MS）、进展型多发性硬化（progressive MS）患者及健康对照者的髓系细胞开展单细胞RNA测序（single-cell RNA sequencing），探究单核细胞在多发性硬化（Multiple Sclerosis, MS）病程进展中的特征变化。研究团队可依据受试者近6个月是否出现持续残疾进展，将原本被归类为进展型多发性硬化的患者分为两个明确亚组：临床进展者（clinical progressor）与非进展者（non-progressors）。