DEMETER 2 Combined RNAi

Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to the combination of three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. This dataset is derived from https://doi.org/10.6084/m9.figshare.6025238.v4 and formatted to more closely match quarterly releases. Specifically, the main matrices have been transposed so that they are indexed by cell line, cell lines are identified by DepMap IDs, and common dependencies and dependency probability estimated. Only select files are included. Refer to the original dataset for all files. See README for more information about files.Visit the Cancer Dependency Map portal at https://depmap.org to explore related datasets. Email questions to [e-mail]使用DEMETER2模型估算的癌细胞系遗传依赖性数据集。DEMETER2模型被应用于三项大规模RNA干扰（RNA interference，简称RNAi）筛选数据集的整合分析：布罗德研究所（Broad Institute）的Achilles项目、诺华（Novartis）的DRIVE项目，以及Marcotte等人的乳腺癌细胞系数据集。本数据集源自https://doi.org/10.6084/m9.figshare.6025238.v4，并为适配季度发布的格式规范进行了优化调整。具体而言，主矩阵已完成转置，以细胞系作为索引；细胞系通过DepMap ID进行标识，并估算得到了通用遗传依赖性与依赖性概率。本次仅收录部分文件，如需获取全部文件，请参考原始数据集。有关文件的详细说明，请参见README文档。可访问癌症依赖性图谱（Cancer Dependency Map，简称DepMap）门户https://depmap.org以探索相关数据集。如有疑问，请发送邮件至[e-mail]。