Immunogenic peptides from APC mutations reported from different databases.

Immunogenic peptides were selected from a library of 9-mer peptides derived from non-synonymous single nucleotide variants and Indels resulting in amino acid alterations. The mutated peptides were selected on the basis of positive TCR binding and an HLA binding affinity of ≤500 nM. *OncoMD is MedGenome Labs’s proprietary database of somatic mutations. LOVD: Leiden Open (source) Variation Database UMD: Universal Mutation Database.*免疫原性肽（immunogenic peptides）选自由非同义单核苷酸变异（non-synonymous single nucleotide variants）及可引发氨基酸改变的插入缺失（Indels）衍生而来的9聚体肽（9-mer peptides）文库。 所筛选的突变肽段需满足T细胞受体（TCR）阳性结合条件，且人类白细胞抗原（HLA）结合亲和力≤500纳摩尔（nM）。 *OncoMD为美基诺实验室（MedGenome Labs）的专有体细胞突变数据库。 LOVD：莱顿开放（源）变异数据库（Leiden Open (source) Variation Database）；UMD：通用突变数据库（Universal Mutation Database）。