Supplementary Material for: Epidemiology of Primary Brain Tumors in the Province of Catania during the 2003–2016 Period

<b><i>Introduction:</i></b> Primary brain tumors (PBTs) account for approximately 2% of all cancers and are associated with significant morbidity and mortality. However, only few epidemiological studies focus on PBTs in Italy. The aim of this study was to evaluate incidence, temporal trend, and survival rate of all PBTs in the province of Catania during the study period. <b><i>Methods:</i></b> All patients diagnosed with PBTs in the province of Catania during the 2003-2016 were identified through the local cancer registry. All cases were classified by histology according to 2007 WHO classification of central nervous system tumors, using the International Classification of Diseases for Oncology, 3rd edition codes. The incidence rate (IR) was calculated for all PBTs and by gender, histology, age-groups, and behavior. Trend analysis was performed using a piecewise log-linear model. <b><i>Results:</i></b> A total of 3,819 cases were identified with a female/male ratio of 1.45. The IR for all PBTs was 25.3/100,000 person-years (95% confidence interval 24.5–26.1). Most PBTs were nonmalignant (59.5%, IR = 15.0) with a female predominance. Conversely, malignant tumors (32.4%, IR = 8.2) were more common among men, with a female/male ratio of 0.9. The most frequently reported histology was meningioma (39.0%, IR = 9.8), followed by glioblastoma (11.6%, IR = 2.9). A peak of incidence was found in the 75–84 years age-group, with an IR of 77.6/100,000 person-years. Overall, no increase in incidence was observed along the study period. <b><i>Conclusions:</i></b> The IR of PBTs in the province of Catania is close to incidence reported worldwide. Further studies on risk factors are necessary.

<b><i>引言：</i></b> 原发性脑肿瘤（Primary Brain Tumors, PBTs）约占所有癌症的2%，且与较高的致残率和死亡率密切相关。然而，目前针对意大利人群原发性脑肿瘤的流行病学研究相对较少。本研究旨在评估研究周期内卡塔尼亚省所有原发性脑肿瘤的发病情况、时间趋势与生存率。<b><i>方法：</i></b> 本研究通过当地癌症登记系统，筛选出2003年至2016年间在卡塔尼亚省被诊断为原发性脑肿瘤的所有患者。所有病例均依据《国际肿瘤疾病分类第3版》（International Classification of Diseases for Oncology, 3rd edition, ICD-O-3）编码，按照2007年世界卫生组织中枢神经系统肿瘤分类标准进行组织学分类。研究计算了所有原发性脑肿瘤的发病率（Incidence Rate, IR），并按性别、组织学类型、年龄组与肿瘤生物学行为进行分层统计。采用分段对数线性模型进行趋势分析。<b><i>结果：</i></b> 本研究共纳入3819例患者，男女比例为1:1.45（女性占比更高）。所有原发性脑肿瘤的总发病率为25.3/10万人年（95%置信区间：24.5~26.1）。其中非恶性肿瘤占比最高，达59.5%，发病率为15.0/10万人年，且以女性居多。反之，恶性肿瘤占比32.4%，发病率为8.2/10万人年，在男性中更为常见，男女比例为0.9:1。最常见的组织学类型为脑膜瘤（占39.0%，发病率9.8/10万人年），其次为胶质母细胞瘤（占11.6%，发病率2.9/10万人年）。发病率在75~84岁年龄组达到峰值，为77.6/10万人年。整体而言，研究周期内原发性脑肿瘤的发病率未出现明显上升趋势。<b><i>结论：</i></b> 卡塔尼亚省原发性脑肿瘤的发病率与全球报道的平均水平相近。后续仍需开展针对其危险因素的深入研究。