MOESM1 of Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Additional file 9. Regulation and function of genes associated with repair pathways during irradiation induced senescence. Differential regulation and function of (i) genes associated with DNA repair (Nucleotide excision, Base excision, Mismatch repair) and (ii) DNA replication pathways on 20 Gy irradiation induced senescence in MRC-5 fibroblasts and HFF strains. Blue color denotes that previous studies have functionally associated these genes with induction of senescence.

附加文件9：辐射诱导细胞衰老过程中与修复通路相关基因的调控与功能。本研究以20 Gy辐射诱导MRC-5成纤维细胞（MRC-5 fibroblasts）与HFF细胞株（HFF strains）发生细胞衰老为模型，分析两类基因的差异调控模式与功能：（i）参与DNA修复的基因（包括核苷酸切除修复（Nucleotide excision repair）、碱基切除修复（Base excision repair）、错配修复（Mismatch repair））；（ii）参与DNA复制通路的相关基因。图中蓝色标记代表既往研究已将这些基因与细胞衰老的诱导过程建立了功能关联。