Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 Descriptor: 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A Authors: Chaikuad, A, Sanvitale, C, Mahajan, P, Daga, N, Cooper, C, Krojer, T, Alfano, I, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) Deposit date: 2010-03-31 Release date: 2010-05-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 To be Published

数据集核心内容：骨形态发生蛋白受体1B型（bone morphogenetic protein receptor type-1B，BMPR1B）的胞质结构域与FKBP12及LDN-193189形成复合物的晶体结构。
详细描述项：配体为4-[6-(4-哌嗪-1-基苯基)吡唑并[1,5-a]嘧啶-3-基]喹啉，研究蛋白包含骨形态发生蛋白受体1B型、肽基脯氨酰顺反异构酶FKBP1A。
作者：Chaikuad, A、Sanvitale, C、Mahajan, P、Daga, N、Cooper, C、Krojer, T、Alfano, I、Knapp, S、von Delft, F、Weigelt, J、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Bullock, A
依托机构：结构基因组学联合会（Structural Genomics Consortium, SGC）
提交日期：2010-03-31
发布日期：2010-05-19
最后修改日期：2023-11-01
解析方法：X射线衍射（分辨率2.05 Å）
引用说明：骨形态发生蛋白受体1B型胞质结构域与FKBP12及LDN-193189复合物的晶体结构，待发表。