Neuron-astroglial communication: Exosomal heparanase isoforms released from astrocyte modulate synaptic strength

This files contains data to support the following experimental results:Results presented in this study provide evidences that heparanase 2 and astrocytes heparanase associated ADEV in response to NMDA stimulation exhibit inhibitory effect to synaptic plasticity by enhancing the bulk internalization of surface AMPA receptors and Syndecan 3 from the neuronal surface. This study is also the first time revealing the microstructure of heparanase associated exosome derived from astrocyte.

本数据集包含支撑下述实验结果的相关数据：本研究呈现的实验结果证实，在N-甲基-D-天冬氨酸（NMDA）刺激下，乙酰肝素酶2（heparanase 2）以及星形胶质细胞（astrocytes）来源的、与乙酰肝素酶相关的ADEV，可通过促进神经元表面α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPA receptors）与多配体蛋白聚糖3（Syndecan 3）的批量内吞作用，对突触可塑性产生抑制效应。本研究同时首次揭示了星形胶质细胞来源的、与乙酰肝素酶相关的外泌体（exosome）的微观结构。