[Metabolic evaluation of a polymer intravaginal device for the administration of calcium and magnesium in ruminants]

ABSTRACT The aim of the study was to evaluate the availability of calcium (Ca2+) from two pharmaceutical forms (oral and intravaginal) and its effect on the metabolism of ruminants. The study was carried out at the experimental farm of the Federal University of Pelotas. Twenty-four lactating ewes were randomly divided into 4 groups: treatment device (TD); control device (DC); oral treatment (OT); and oral control (OC). Treated animals received calcium formate and magnesium chloride, evaluations were performed after administration of the treatments. Total calcium (CaT), magnesium (Mg), total plasma proteins (PPT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), urea, albumin and urinary pH, and clinical examination were performed on all animals. Serum CaT, CaI and Mg levels differed between the groups (P≤ 0.05), the animals in the DT and DC groups differed in the three evaluations, the DT group had the highest mean values, being significantly equal to the OT group. There was no difference in the serum concentrations of PPT, AST, GGT, Albumin, Urea and urinary pH. In conclusion, the blood availability of CaT, CaI and Mg is the same when administration of calcium and magnesium formate is intravaginal or orally, without altering other metabolic parameters evaluated.

摘要
本研究旨在评估两种药剂剂型（口服与阴道内给药）的钙（calcium, Ca²+）生物利用度，及其对反刍动物代谢的影响。本研究在佩洛塔斯联邦大学（Federal University of Pelotas）的实验农场开展。将24头泌乳母羊随机分为4组：给药装置组（treatment device, TD）、空白装置组（control device, DC）、口服给药组（oral treatment, OT）与口服对照组（oral control, OC）。给药组动物给予甲酸钙与氯化镁，于给药后开展各项检测。对所有动物检测总钙（total calcium, CaT）、镁（magnesium, Mg）、血浆总蛋白（total plasma proteins, PPT）、天冬氨酸氨基转移酶（aspartate aminotransferase, AST）、γ-谷氨酰转移酶（gamma glutamyl transpeptidase, GGT）、尿素、白蛋白及尿液pH，并进行临床检查。各组血清总钙（CaT）、离子钙（calcium ionized, CaI）与镁（Mg）水平存在显著差异（P≤0.05）；给药装置组（TD）与空白装置组（DC）在三项检测指标中均存在差异，给药装置组平均水平最高，且与口服给药组（OT）无显著差异。各组血清总蛋白（PPT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转移酶（GGT）、白蛋白、尿素浓度及尿液pH均无显著差异。综上，经阴道内或口服给予甲酸钙与氯化镁时，血清总钙、离子钙及镁的血液生物利用度无显著差异，且不会改变本次评估的其他代谢参数。