THE INFECTION OF PRENATAL INFECTIOUS FACTORS ON THE ANATOMICAL DEVELOPMENT OF THE SKULL AND CENTRAL NERVOUS SYSTEM AND THE DEVELOPMENT OF BEHAVIORAL DISORDERS IN CHILDREN

Infectious factors in the prenatal period can have a negative impact on the formation of the fetal brain and skull. In particular, infections belonging to the TORCH group of infections disrupt the morphogenesis of the central nervous system, leading to cranial anomalies and neuroanatomical changes. Under the influence of prenatal infection, the processes of proliferation and migration of neurons are disrupted, which increases the risk of developing cognitive and behavioral disorders. For example, congenital cytomegalovirus infection and congenital toxoplasmosis are common causes of central nervous system damage.产前感染因素可对胎儿大脑与颅骨的发育造成不良影响。具体而言，TORCH感染（TORCH）可干扰中枢神经系统的形态发生过程，引发颅骨畸形及神经解剖结构改变。受产前感染影响，神经元的增殖与迁移过程会受到破坏，进而增加认知与行为障碍的发病风险。例如，先天性巨细胞病毒感染与先天性弓形虫病是引发中枢神经系统损伤的常见病因。