Supplemental Table 2 from Rare Variation in <i>TET2</i> Is Associated with Clinically Relevant Prostate Carcinoma in African Americans

Deleterious variants in 800 genes selected for targeted sequencing. Using the combined dataset (discovery + extension), for each gene, the fraction of controls and cases harboring at least one rare (MAF<5%) deleterious (nonsense, splice site, frameshift, or damaging missense) variant are shown, along with the p-values from Fisher's Exact Test (FET) and a newer implementation of the Sequence Kernel Association Test (SKAT-O).本数据集涵盖经筛选用于靶向测序的800个基因中的有害变异。采用合并后的数据集（发现集+扩展集），针对每个基因，展示了对照组与病例组中携带至少1种罕见（次要等位基因频率（Minor Allele Frequency, MAF）<5%）有害变异——涵盖无义突变、剪接位点变异、移码突变或有害错义突变——的个体比例，同时给出费希尔精确检验（Fisher's Exact Test, FET）与新型序列核关联检验（Sequence Kernel Association Test, SKAT-O）的p值。