Harnessing_transposons_for_drug_resistance_gene_discovery_in_cancer

In the last decade we have begun to move towards the use of targeted therapeutics in the clinic, often resulting in dramatic response rates in cancer patients. However, clinical experience has demonstrated time and time again that such responses are invariably followed by the development of drug resistance. Identification of the underlying mechanisms may enable us to reverse such resistance. Traditional methods of modelling this resistance in vitro can lead to a plethora of potential resistance mechanisms that can be difficult to decipher.

近十年来，临床领域已逐步转向靶向治疗药物的应用，这类疗法往往能让癌症患者获得显著的应答率。然而临床经验反复证实，这类应答往往无一例外会伴随耐药性的产生。明确其潜在作用机制，或可帮助我们逆转此类耐药性。传统的体外耐药模型构建方法，往往会衍生出大量潜在耐药机制，却难以对其进行解析与阐明。