The cost-effectiveness of a uniform versus age-based threshold for one-off screening for prevention of cardiovascular disease

The objective of these analyses was to assess the cost-effectiveness of screening strategies for CVD. A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform”: adj0 or “age-adjusted”: adj1). The analyses for men are performed in the spreadheet 'CVD_Screening_5_state_epiccvd_probs_exact_men_trend.determin.xlsx' which uses inputs from epiccvd_mstate_input_agescale_nfrs_1_frs08v3_sex1_v01.xlsx. The outputs (costs and QALYs) are copied into men.xlsx to calculate the net benefit of different screening strategies. Further explications are given in the spreadsheet 'CVD_Screening_5_state_epiccvd_probs_exact_men_trend.determin.xlsx'.

本分析旨在评估心血管疾病（Cardiovascular Disease, CVD）筛查策略的成本效益。本研究构建了决策分析模型，用于估算按筛查年龄、性别及他汀类药物启动阈值（"统一阈值"：adj0；"年龄调整阈值"：adj1）划分的一次性筛查策略的成本与收益。针对男性群体的分析在电子表格`CVD_Screening_5_state_epiccvd_probs_exact_men_trend.determin.xlsx`中开展，该表格的输入数据源自`epiccvd_mstate_input_agescale_nfrs_1_frs08v3_sex1_v01.xlsx`。分析所得的成本与质量调整生命年（Quality-Adjusted Life Years, QALYs）数据将被导入`men.xlsx`，用于计算不同筛查策略的净效益。该电子表格`CVD_Screening_5_state_epiccvd_probs_exact_men_trend.determin.xlsx`中还附有进一步的详细说明。