Data for: A yolk shell Fe3O4 @PA-Ni@Pd/Chitosan nanocomposite -Modified carbon ionic liquid electrode as a New Sensor for the Sensitive Determination of fluconazole in Pharmaceutical Preparations and Biological Fluids

In this study, a versatile method was used to synthesize Ni@Pd core–shell nanoparticles, immobilized on Fe3O4@polyaniline yolk–shell composites (Fe3O4@PA) as a novel electrode modifier. Up to now, application of this nanoparticles have not been reported. The constructed nanocomposite and Chitosan were utilized for the modification of carbon ionic liquid electrode (CILE) for high sensitive determination of fluconazole in biological and pharmaceutical samples. By using response surface methodology and input data, the graphical relationship between responses and variables is obtained and the multiple regression analysis can be carried out.

本研究采用通用合成方法制备了镍@钯（Ni@Pd）核壳纳米颗粒，并将其负载于四氧化三铁@聚苯胺蛋黄壳型复合材料（Fe3O4@PA）上，作为新型电极修饰剂。截至目前，此类纳米颗粒的相关应用尚未见文献报道。将所制备的纳米复合材料与壳聚糖（Chitosan）共同用于碳离子液体电极（CILE）的修饰，以实现生物样本与药物样本中氟康唑（fluconazole）的高灵敏度检测。通过响应面法（response surface methodology）与输入数据，可获得响应值与变量间的图形关系，并开展多元回归分析。