Effects of Buyang Huanwu Decoction on circRNA-miRNA-mRNA transcriptional network of rats with cerebral ischemia. Effects of Buyang Huanwu Decoction on circRNA-miRNA-mRNA transcriptional network of rats with cerebral ischemia

To reveal the effects of Buyang Huanwu Decoction on circRNA-miRNA-mRNA transcriptional network of rats with cerebral ischemia, explore its molecular mechanism for the treatment of cerebral ischemia. Overall design: Three-condition experiment: control group, model group and Buyang Huanwu Decoction(BHD) group.The middle cerebral artery embolization method was used to replicate the cerebral ischemia model in all groups

为揭示补阳还五汤对脑缺血大鼠环状RNA（circRNA）-微小RNA（miRNA）-信使RNA（mRNA）转录调控网络的影响，探讨其治疗脑缺血的分子作用机制。实验整体设计：设置三组对照实验，分别为对照组、模型组与补阳还五汤（BHD）组。所有组别均采用大脑中动脉栓塞法复制脑缺血模型。