ATN 071 Behavior Rating Inventory of Executive Function – Adult Version (BRIEF-A) Primary Dataset in Neurocognitive Assessment in Youth Initiating HAART

Data from Behavior Rating Inventory of Executive Function – Adult Version (BRIEF-A) [CRF f14]
Study Description
A prospective cohort study comparing neurocognitive functioning in four groups of youth, ages 18-24 years, with behaviorally acquired HIV infection: two groups with CD4+ T-cells greater than 350 cells/mm3 and HIV RNA equal to or greater than 1,000 copies/ml - one initiating early highly active antiretroviral therapy (HAART) (Group 1), the other not initiating treatment (Group 2); and two groups with CD4+ T-cells less than 350 cells/mm3 - one initiating HAART according to then current DHHS guidelines (Group 3), the other not initiating treatment (Group 4). Groups 2 and 3 represented standard of care. The study provided preliminary data to test the hypothesis that initiating HAART earlier than DHHS guidelines suggested at that time resulted in better neurocognitive function in comparison with no treatment or treatment initiated according to DHHS recommendations. Youth ages 18-24 years with behaviorally acquired HIV infection

本数据集源自执行功能行为评定量表成人版（Behavior Rating Inventory of Executive Function – Adult Version, BRIEF-A）[CRF f14]。
研究概况
本研究为一项前瞻性队列研究，对比四组18~24岁经性行为感染HIV的青年的神经认知功能：两组CD4+T淋巴细胞计数＞350cells/mm³且HIV RNA≥1000拷贝/ml的青年，其中一组早期启动高效抗反转录病毒治疗（highly active antiretroviral therapy, HAART）（队列1），另一组未启动治疗（队列2）；另外两组CD4+T淋巴细胞计数＜350cells/mm³的青年，其中一组按照当时美国卫生与公众服务部（Department of Health and Human Services, DHHS）指南启动HAART治疗（队列3），另一组未启动治疗（队列4）。队列2与队列3代表当时的临床标准治疗方案。本研究旨在验证假说：相较于未接受治疗或按照DHHS指南启动治疗的队列，提前于当时指南推荐时机启动HAART治疗可使患者获得更优的神经认知功能。本研究的纳入对象为18~24岁经性行为感染HIV的青年。