Supplementary Material for: Automated Whole Cochlear T2 Signal Demonstrates Weak Correlation with Hearing Loss in Observed Vestibular Schwannoma

<b><i>Introduction:</i></b> We sought to evaluate the correlation between whole cochlear T2 signal changes obtained with a novel automated segmentation method and hearing levels, both at diagnosis and over time, in patients with observed vestibular schwannoma. <b><i>Methods:</i></b> This retrospective correlation study within an academic medical center neurotology practice evaluated 127 patients with vestibular schwannoma observed over time, each with ≥2 MRI scans (367 total) and ≥2 audiograms (472 total). 86 patients had T2-weighted sequences with sufficient resolution for cochlear signal analysis, yielding 348 unique timepoint intervals. The main outcome measure was correlation of the ipsilateral-to-contralateral ratio of whole cochlear T2 signal with hearing outcomes as measured by pure tone average (PTA) and word recognition score (WRS). <b><i>Results:</i></b> Whole cochlear T2 signal ratios did not show a correlation with hearing levels at diagnosis. Change in signal ratio over time showed weak correlation with changes in PTA, but not WRS, over time. Cochlear signal ratio did not precede changes in hearing but did follow changes in both PTA and WRS. <b><i>Conclusion:</i></b> Whole cochlear T2 signal ratios were weakly correlated with changes in hearing in patients with observed vestibular schwannoma. The technology of automated segmentation and signal processing holds promise for future evaluation of clinical entities causing cochlear signal changes.

**引言**：本研究旨在评估采用新型自动化分割方法获取的全耳蜗T2信号变化，与经长期随访观察的前庭神经鞘瘤（vestibular schwannoma）患者在确诊时及随时间推移的听力水平之间的相关性。
**方法**：本研究为一项在学术医疗中心耳神经学临床实践中开展的回顾性相关性研究，共纳入127例经长期随访观察的前庭神经鞘瘤患者，所有患者均完成≥2次磁共振成像（Magnetic Resonance Imaging, MRI）扫描（总计367次）及≥2次听力图检查（总计472次）。其中86例患者的T2加权序列具备足够分辨率以开展耳蜗信号分析，最终得到348个独立的时间点间隔。本研究的主要结局指标为全耳蜗T2信号同侧/对侧比值与以纯音平均听阈（pure tone average, PTA）及言语识别率（word recognition score, WRS）衡量的听力结局之间的相关性。
**结果**：全耳蜗T2信号比值在确诊时与患者的听力水平无相关性。随时间推移的信号比值变化与纯音平均听阈的变化呈弱相关，但与言语识别率的变化无相关性。耳蜗信号比值并未先于听力变化出现，而是滞后于纯音平均听阈及言语识别率的变化。
**结论**：在经长期观察的前庭神经鞘瘤患者中，全耳蜗T2信号比值与听力变化呈弱相关。自动化分割与信号处理技术有望在未来用于评估引发耳蜗信号变化的临床病症。