Overview of cytokine analyses.

Overview of the significant associations of all analyses performed and specified per cytokine. The Mann-Whitney U test was used to compare the groups with each other. Abbreviations: HC: healthy control. 2009 WHO classification: WS-: non-severe dengue without warning signs, WS+: non-severe dengue with warning signs, Sev: severe dengue. Plasma leakage/shock: No : no plasma leakage occured, PL: plasma leakage detected, Hemorrhage: No : no hemorrhagic symptoms, Minor: minor hemorrhage, Sev: severe hemorrhage. Temporal pattern: D1-3: day 1-3 after the onset of fever, D4-7: day 4-7 after the onset of fever, D>7: more than 7 days after the onset of fever. Cluster analysis: * only in a part of the cluster this cytokine is up- or downregulated. Conclusions: CC: clinical classification, CA: cluster analysis.本部分概述了所有已开展且针对每种细胞因子（cytokine）明确的分析的显著关联。本研究采用曼-惠特尼U检验（Mann-Whitney U test）进行组间两两比较。缩写说明：HC：健康对照（healthy control）。2009年世界卫生组织（WHO）分类标准：WS-：无警示体征的非重症登革热，WS+：伴警示体征的非重症登革热，Sev：重症登革热。血浆渗漏/休克情况：无：未发生血浆渗漏，PL：检测到血浆渗漏；出血情况：无：无出血症状，Minor：轻度出血，Sev：重度出血。时间分布模式：D1-3：发热起病后1~3天，D4-7：发热起病后4~7天，D>7：发热起病后7天以上。聚类分析：* 仅在部分亚簇中，该细胞因子存在表达上调或下调。结论相关说明：CC：临床分类，CA：聚类分析。