Proteome analysis of huntingtin knock-in allelic series - Cerebellum

The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, cerebellum samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quantitative, label-free proteome analysis was performed using Evotec’s quantitative Deep Proteome Profiling technology.

本项目旨在研究小鼠亨廷顿蛋白（huntingtin）敲入等位基因系列不同组织中的蛋白质组。在本研究的当前阶段，我们对采集自2、6、10月龄的完整留存等位基因系列的小脑样本进行了分析。为此，我们采用Evotec的定量深度蛋白质组分析技术，开展了全面的无标记定量蛋白质组分析。