Summary of ChIP-seq results showing localization of PhoP binding sites in the M. tuberculosis genome.

The table lists regions enriched in immunoprecipitated PhoP-DNA complexes from the H37Rv wild type strain as compared to the phoP mutant. Fold change expression values as determined by RNA-seq experiments are also reported for the flanking genes. Predicted or validated operons found to be deregulated in the phoP mutant are indicated.ap value bFDR 0.00%.cThis column lists the predicted operons (according to [17], [18], [19]), located downstream of PhoP binding sites, that were found to be deregulated in the phoP mutant compared to the wild type strain.§Region detected is between two genes transcribed in opposite direction.£Region located in 3′-end of the gene.ND: fold change expression levels of phoP were not quantified since the gene carries a deletion in the mutant strain.本表格列出了相较于phoP突变株，H37Rv野生型菌株中经免疫共沉淀（immunoprecipitation）富集的PhoP-DNA复合物结合区域。同时还报告了通过RNA-seq实验测定的侧翼基因的表达倍数变化值。本研究标注了在phoP突变株中存在表达失调的预测型或已验证型操纵子（operon）。 a p值；b 假发现率（false discovery rate, FDR）<0.00%。 c 本列列出了依据文献[17]、[18]、[19]预测的、位于PhoP结合位点下游的操纵子，这些操纵子在相较于野生型菌株的phoP突变株中被检测到存在表达失调。 § 所检测区域位于两个反向转录的基因之间。 £ 该区域位于基因的3'端。 ND：由于phoP基因在突变株中存在缺失突变，因此未对其表达倍数变化水平进行定量检测。