The Impact of the Geometric Characteristics on the Hemodynamics in the Stenotic Coronary Artery

The alterations of the hemodynamics in the coronary arteries, which result from patient-specific geometric significances are complex. The effect of the stenosis on the blood flow alteration had been wildly reported, but the combinational contribution from geometric factors required a comprehensive investigation to provide patient-specific information for diagnosis and assisting in the decision on the further treatment strategies. In the present study, we investigated the correlation between hemodynamic parameters and individual geometric factors in the patient-specific coronary arteries. Computational fluid dynamic simulations were performed on 22 patient-specific 3-dimensional coronary artery models that were reconstructed based on computed tomography angiography images. Our results showed that the increasing severity of the stenosis is associated with the increased maximum wall shear stress at the stenosis region (r = 0.752, P由患者特异性几何特征引发的冠状动脉血流动力学（hemodynamics）改变，其机制十分复杂。尽管动脉狭窄对血流改变的影响已有大量报道，但几何因素的联合作用仍需开展全面研究，以获取患者特异性的诊断信息，并辅助制定后续治疗策略。本研究针对患者特异性冠状动脉（coronary arteries）模型，探究了血流动力学参数与个体几何因素之间的关联。本研究基于计算机断层血管造影（computed tomography angiography, CTA）影像重建了22例患者特异性三维冠状动脉模型，并对其开展了计算流体动力学（computational fluid dynamic, CFD）仿真。研究结果显示，狭窄程度的加重与狭窄区域的最大壁面切应力（wall shear stress, WSS）升高呈显著相关（r = 0.752, P