Porcine Kidney-15 cells LC-MS/MS

Senecavirus A (SVA), which is associated with swine vesicular disease, is an emerging pathogen that caused considerable damages to Chinese pig industrial. As a powerful research method, proteomic provides clues for diseases diagnose, medicine targets selection and pathogenic immunity researches. By using of proteomic to study PK-15 cells infected with SVA SDta/2018 strain, this research aimed to obtain insights and clues for investigating pathogenesis of SVA, viral immune escape mechanism and viruses induced impacts to host immune response.

塞尼卡病毒A型（Senecavirus A, SVA）是一种与猪水疱病相关的新兴病原体，曾对中国养猪产业造成了显著损害。蛋白质组学（proteomics）作为一种高效的研究手段，可为疾病诊断、药物靶点筛选以及病原免疫相关研究提供关键线索。本研究通过蛋白质组学技术分析感染SVA SDta/2018毒株的PK-15细胞，旨在为解析塞尼卡病毒A型的致病机制、病毒免疫逃逸机制以及病毒对宿主免疫应答的影响提供思路与线索。