Proteogenomic Re-annotation of Coccidioides posadasii strain Silveira

The aims of this study were to present modifications to the annotations of the genome of C. posadasii, one of two closely related species of Coccidioides, a dimorphic fungal pathogen that causes coccidioidomycosis, also called Valley Fever. Proteins present in lysates and filtrates of in vitro grown mycelia and parasitic phase spherules from C. posadasii strain Silveira were analyzed using a GeLC-MS/MS method.

本研究旨在修正波萨达斯球孢子菌（C. posadasii）的基因组注释。该菌为球孢子菌属（Coccidioides）两种亲缘关系密切的物种之一，属于可引发球孢子菌病（又称山谷热，Valley Fever）的二态性真菌病原体。本研究采用凝胶液相色谱-串联质谱法（GeLC-MS/MS），对体外培养的波萨达斯球孢子菌Silveira菌株的菌丝体与寄生相球状体的裂解液及滤液中的蛋白质进行了分析。