Effects of FTY720 on B cells in experimental autoimmune encephalomyelitis (EAE). Mus musculus

MP4-induced experimental autoimmune encephalomyelitis (EAE) is a B cell-dependent mouse model of multiple sclerosis (MS), which enables targeted research on B cells, currently much discussed protagonists in MS pathogenesis. Here, we used this model to study the impact of the S1P1 receptor modulator FTY720 (fingolimod) on the autoreactive B cell and antibody response both in the periphery and central nervous system (CNS) itself. Overall design: Expression profiling of S1P1 receptor modulator FTY720- and vehicle-treated B cells from EAE mice.

MP4诱导的实验性自身免疫性脑脊髓炎 (experimental autoimmune encephalomyelitis, EAE) 是一种依赖B细胞的多发性硬化 (multiple sclerosis, MS) 小鼠模型，可用于靶向研究B细胞——这类细胞是当前多发性硬化发病机制中广受关注的核心效应细胞。本研究依托该模型，探究S1P1受体调节剂FTY720 (fingolimod，芬戈莫德) 对多发性硬化外周及中枢神经系统 (central nervous system, CNS) 内自身反应性B细胞与抗体应答的影响。实验整体设计：对经FTY720及赋形剂处理的EAE小鼠体内分离的B细胞进行表达谱分析。