Crystal structure of RXR alpha LBD bound to a synthetic agonist FN558 and a coactivator fragment

Crystal structure of RXR alpha LBD bound to a synthetic agonist FN558 and a coactivator fragment Descriptor: FN558, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha Authors: Morozov, V, Nawa, F, Merk, D. Deposit date: 2025-06-18 Release date: 2025-08-13 Last modified: 2025-08-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Development of an RXR Agonist Scaffold with Pronounced Homodimer Preference. J.Med.Chem., 68, 2025

结合合成激动剂FN558与共激活因子片段的视黄酸受体RXR-α配体结合域（Ligand Binding Domain, LBD）的晶体结构。相关组分：FN558、核受体共激活因子2（Nuclear receptor coactivator 2）、视黄酸受体RXR-α。作者：Morozov V、Nawa F、Merk D。提交日期：2025-06-18；发布日期：2025-08-13；最后修改日期：2025-08-27。实验方法：X射线衍射（分辨率1.65埃）。引用文献：《具有显著同二聚体偏好性的RXR激动剂骨架开发》，《药物化学杂志》（J. Med. Chem.），第68卷，2025年。