Supramolecular Hydrogel Derived from a <i>C</i>₃‑Symmetric Boronic Acid Derivative for Stimuli-Responsive Release of Insulin and Doxorubicin

A C3-symmetric triazine based triboronic acid (HG1) was designed and synthesized. HG1 was found to give hydrogel in DMSO–water (1:9). The hydrogel was rheo-reversible and thermoreversible over a few cycles. Single-crystal X-ray diffraction (SXRD) studies on the crystals of HG1 established the presence of honeycomb network in which solvent molecules (DMSO and water) were occluded. SXRD data corroborated well with the hypothesis based on which HG1 was designed. Stimuli responsive release (in vitro) of insulin and doxorubicin from the hydrogel was also achieved.设计并合成了一种具有C3对称性的三嗪基三硼酸类化合物HG1。研究表明，HG1在体积比为1:9的二甲基亚砜（DMSO）-水混合溶剂中可形成水凝胶。该水凝胶具备流变可逆性与热可逆性，且可经多次循环维持可逆性能。对HG1单晶开展的单晶X射线衍射（Single-crystal X-ray diffraction, SXRD）研究证实，其晶体中存在由溶剂分子（DMSO与水）包埋的蜂窝状网络结构。SXRD测试数据与HG1的设计假说高度契合。此外，该水凝胶还实现了胰岛素与多柔比星（doxorubicin）的体外刺激响应释放。