Data from: Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific. Naturally acquired antibody responses against multiple P. vivax proteins have been described in numerous countries, however, direct comparison of these responses has been difficult with different methodologies employed. We measured antibody responses against 307 P. vivax proteins at the time of P. vivax infection, and at 2–3 later time-points in three countries. We observed that seropositivity rates at the time of infection were highest in Thailand, followed by Brazil then PNG, reflecting the level of antigenic input. The majority of sero-reactive antigens in all sites induced short-lived antibody responses with estimated half-lives of less than 6 months, although there was a trend towards longer-lived responses in PNG children. Despite these differences, IgG seropositivity rates, magnitude and longevity were highly and significantly rank-correlated between the different regions, suggesting such features are reflective of the individual protein.

间日疟原虫(Plasmodium vivax)仍是南美洲及亚太地区重要的疟疾致病原。目前已有多项研究在多个国家报道了针对多种间日疟原虫蛋白的自然获得性抗体应答，但由于各研究采用的实验方法存在差异，难以对这些抗体应答进行直接比较。本研究在泰国、巴西与巴布亚新几内亚(PNG)三个国家，于间日疟原虫感染即刻以及感染后2至3个后续时间点，对针对307种间日疟原虫蛋白的抗体应答进行了检测。研究观察到，感染即刻的血清阳性率以泰国最高，其次为巴西，再为巴布亚新几内亚，这一结果反映了当地的抗原暴露水平。所有研究地点的多数血清反应原均可诱导半衰期不足6个月的短效抗体应答，不过巴布亚新几内亚儿童群体中存在抗体应答半衰期更长的趋势。尽管存在上述差异，不同区域之间的IgG血清阳性率、抗体水平与应答持久性均呈现高度显著的秩相关关系，表明这些特征是由单个蛋白本身所决定的。