Data set for the main analysis .

Background Sex workers of all genders have a high risk of HIV acquisition and are a priority population for HIV pre-exposure prophylaxis (PrEP). We aimed to assess current oral PrEP use and associated factors among cisgender female sex workers (FSW) in two Ugandan cities. Methods We administered a survey questionnaire to 236 HIV-negative FSW in the cities of Mbale and Mbarara from January to March 2020. The survey was nested in a quasi-experimental study to assess the effect of peer education and text message reminders on the uptake of regular sexually transmitted infection (STI) and HIV testing. Using interviewer-administered questionnaires, we obtained data on current self-reported tenofovir-based oral PrEP use. We used modified Poisson regression with robust standard errors to evaluate the factors associated with current oral PrEP usage. Results Nearly 70% of FSWs reported taking an HIV test during the past three months. Among the respondents, 33% (33/100) in Mbale and 67% (91/136) in Mbarara reported having ever heard of PrEP. However, only 9.7% (23/236) self-reported currently taking oral-PrEP. In Mbarara, FSWs were twice as likely to be aware of or use oral PrEP than those in Mbale (adjusted prevalence ratio [aPR] 2.33; 95% confidence interval (CI) 1.19–3.97; p = 0.01). Additionally, current use was positively associated with attainment of secondary (aPR 2.50; 95% CI: 1.14–5.45; p = 0.02) or tertiary education (aPR 3.12; 95% CI: 1.09–8.96; p = 0.03). Conclusion PrEP use in this cohort of FSWs was low and was associated with location and level of education. To increase PrEP uptake among FSWs, targeted educational campaigns and implementation studies are needed, particularly for those with lower levels of education.背景 所有性别的性工作者均为人类免疫缺陷病毒（HIV）感染高风险人群，亦是艾滋病病毒暴露前预防（pre-exposure prophylaxis, PrEP）的重点关注人群。本研究旨在评估乌干达两座城市中顺性别女性性工作者（cisgender female sex workers, FSW）目前的口服PrEP使用现状及其相关影响因素。 研究方法 本研究于2020年1月至3月间，在姆巴莱（Mbale）与姆巴拉拉（Mbarara）两座城市，纳入236名HIV阴性女性性工作者开展问卷调查。本次调查嵌套于一项准实验研究，该研究旨在评估同伴教育与短信提醒对常规性传播感染（sexually transmitted infection, STI）及HIV检测参与率的提升效果。研究采用访员访谈式问卷，收集受试者自我报告的当前基于替诺福韦的口服PrEP使用情况数据。本研究使用带有稳健标准误的修正泊松回归模型，分析当前口服PrEP使用的相关影响因素。 研究结果 近70%的女性性工作者报告称在过去三个月内接受过HIV检测。受访者中，姆巴莱地区有33%（33/100）、姆巴拉拉地区有67%（91/136）的人群曾听说过PrEP。但仅有9.7%（23/236）的受试者自我报告目前正在使用口服PrEP。在姆巴拉拉地区，女性性工作者知晓或使用口服PrEP的概率是姆巴莱地区的两倍（校正患病率比[aPR] 2.33；95%置信区间[CI] 1.19–3.97；P=0.01）。此外，当前口服PrEP使用与中等教育程度（aPR 2.50；95%CI：1.14–5.45；P=0.02）及高等教育程度（aPR 3.12；95%CI：1.09–8.96；P=0.03）呈正相关。 研究结论 本研究队列中的女性性工作者PrEP使用率较低，且与所在地区及受教育程度密切相关。为提升女性性工作者的PrEP接受率，需开展针对性的教育宣传活动与实施研究，尤其应关注受教育程度较低的人群。