Swedish Cervical Screening Samples 2011-2021

The Cervical Screening Cohort enrols women screened for human papillomavirus (HPV) and cervical abnormalities within the capital region of Sweden, both from the organised screening program and the non-organised testing of cervical samples. The cohort started in 2011 and has enrolled more than 670,000 women at more than 1.2 million screening visits. Most women have contributed, on average, with two samples between 2011 and 2022. The enrolment process uses written invitations and informed consent, including an opt-out procedure. The cohort data is systematically updated with individual-level data from the Swedish National Cervical Screening Registry (NKCx). Key variables include birthdate, sampling date, cytological and HPV analysis results, histopathological diagnoses (results of cervical biopsies or conisations), and screening invitations, including the invitation date. Each round of sampling and subsequent clinical follow-up is sequentially saved in the database, allowing for longitudinal analyses of screening results and associated results of the clinical workup. Systematic epigenomics and metagenomics analyses performed on the samples enrich the cohort data.
The cohort is ideal for longitudinal, long-term follow-up studies due to its validated documentation and registry-derived information. From the data, it is possible to penetrate important human health mechanisms. The data are available as open-access, GDPR-compliant. Samples are available after getting the required permissions. Results will help researchers understand factors that increase cancer risk and other diseases.

宫颈筛查队列（Cervical Screening Cohort）纳入瑞典首都地区接受人乳头瘤病毒（HPV）与宫颈异常筛查的女性，研究对象涵盖官方组织的宫颈癌筛查项目与非官方组织的宫颈样本检测两类人群。该队列始建于2011年，目前已累计纳入超67万名女性，完成超120万次筛查就诊。2011至2022年间，多数女性平均贡献了2份筛查样本。
队列招募采用书面邀请与知情同意流程，包含自愿退出机制。该队列数据依托瑞典国家宫颈筛查登记库（Swedish National Cervical Screening Registry，缩写NKCx）的个体层面数据进行系统性更新。核心变量涵盖出生日期、采样日期、细胞学与HPV检测结果、组织病理学诊断（宫颈活检或宫颈锥切术结果）以及筛查邀请信息（含邀请日期）。每一轮采样及后续临床随访数据均按时间顺序存入数据库，支持对筛查结果与临床诊疗相关结果开展纵向分析。针对样本开展的系统性表观基因组学与宏基因组学分析进一步丰富了该队列的数据资源。
得益于经过验证的文档记录与登记库来源的权威数据，该队列非常适用于纵向长期随访研究。依托该数据集，可深入解析人体健康的关键机制。该数据集以开放获取形式发布，且符合通用数据保护条例（General Data Protection Regulation，GDPR）规范。样本资源需经申请获得相应审批权限后方可获取。相关研究成果将助力研究者明确癌症及其他疾病的风险升高相关因素。