Fig.3

<strong>Figure 3 TFA inhibited migration, proliferation, collagen synthesis of intestinal fibroblast</strong> A. In IGF-induced intestinal fibroblast cells, the wound closure rate was obviously higher that in control group. . B. The migration ability was stronger in IGF-induced intestinal fibroblast cells. C.TFA improved proliferation in IGF-induced models. D. The levels of COX-2, NMP-2 and NMP-9 was significantly higher than control, while TFA down-regulated the expression of these genes. E. The expressions of fibrous collagen related genes (Col1a1 and Col3a1). ***P &lt; 0.001, Vs model group, ## P &lt; 0.01, ### P &lt; 0.001.

图3 TFA可抑制肠道成纤维细胞的迁移、增殖与胶原合成
A. 经胰岛素样生长因子（IGF）诱导的肠道成纤维细胞，其伤口愈合率显著高于对照组。
B. IGF诱导的肠道成纤维细胞迁移能力更强。
C. TFA可改善IGF诱导模型中的细胞增殖状态。
D. 模型组的环氧合酶-2（COX-2）、NMP-2与NMP-9表达水平显著高于对照组，而TFA可下调上述基因的表达。
E. 纤维胶原相关基因（Col1a1与Col3a1）的表达水平。
***P < 0.001，与模型组比较；## P < 0.01，### P < 0.001。