Substrate-Controlled Regioselective Arylations of 2‑Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3′-Bisindole Derivatives

A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been established, which efficiently afforded bis­(indolyl)­methane and 3,3′-bisindole derivatives in high yields and with a broad substrate scope (up to 98% yield, 36 examples). This approach will not only provide an important strategy for the diversified synthesis of bis­(indolyl)­methane and 3,3′-bisindole derivatives but also serve as a good example for substrate-controlled regioselective reactions.已开发出一种底物控制区域选择性的吲哚与2-吲哚甲醇的芳基化反应，该反应可高效合成双吲哚甲烷与3,3'-双吲哚类衍生物，产率优异且底物适用范围广（产率最高达98%，共36个反应实例）。该策略不仅为双吲哚甲烷及3,3'-双吲哚类衍生物的多样化合成提供了重要途径，同时也为底物控制的区域选择性反应提供了良好范例。