Genome_choleratoxin1

霍乱是由霍乱弧菌引起的高度传染性疾病，危害人类健康，造成经济损失，使公共卫生服务不堪重负。尽管霍乱弧菌对人类健康的影响已得到广泛研究，但关于霍乱弧菌在不同环境中获取和传播霍乱毒素基因的信息有限。在这项工作中，我们通过从 IMG/VR、Refseq 和 Enterobase 数据库中收集含有霍乱毒素基因的病毒和细菌基因组，研究了不同栖息地病毒之间霍乱毒素基因的转移。在RefSeq、EnteroBase数据库和多个生境的细菌MAGs（超过1,165,144个细菌基因组）中检索了霍乱弧菌和含有毒素基因的细菌基因组，共鉴定出4,625个霍乱弧菌基因组和6,947个含有毒素基因的细菌基因组。在综合微生物基因组和病毒组（IMG/VR）数据库（v4.1,2022年9月）中共鉴定出453个编码毒素基因的中高质量UViG。

Cholera is a highly contagious disease caused by Vibrio cholerae, which endangers human health, causes economic losses, and overwhelms public health services. Although the impacts of Vibrio cholerae on human health have been extensively studied, information regarding how Vibrio cholerae acquires and transmits cholera toxin genes across different environments remains limited. In this work, we investigated the transfer of cholera toxin genes among viruses from distinct habitats by collecting viral and bacterial genomes carrying cholera toxin genes from the IMG/VR, RefSeq, and Enterobase databases. We retrieved Vibrio cholerae genomes and bacterial genomes carrying toxin genes from the RefSeq, EnteroBase databases, and bacterial MAGs from multiple habitats (over 1,165,144 bacterial genomes in total), identifying a total of 4,625 Vibrio cholerae genomes and 6,947 bacterial genomes carrying toxin genes. A total of 453 medium-to-high quality UViGs encoding toxin genes were identified in the Integrated Microbial Genomes and Virome (IMG/VR) database (v4.1, September 2022).