Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity

We analyzed function of DHX38 helicase in RNA splicing. We downregulated DHX38 in HEK293 cells by RNAi and compared the transcriptome of DHX38 knockdown cells with cells treated with negative control siRNA.本研究探究了DHX38解旋酶（DHX38 helicase）在RNA剪接过程中的功能。我们通过RNA干扰（RNAi）在HEK293细胞中下调DHX38的表达，并将DHX38敲低细胞的转录组与阴性对照小干扰RNA（siRNA）处理组细胞的转录组进行了对比分析。